Jacob Corn trained with James Berger, where his work helped redefine the organization of the bacterial replication fork, and with David Baker, where he computationally designed protein-protein interactions from scratch. Seeking to directly impact human health, Jacob then became a group and project team leader at Genentech in the department of Early Discovery Biochemistry, leading multidisciplinary teams to interrogate mechanism and feasibility for challenging therapeutic pathways in the areas of neurobiology, infectious disease, and oncology. While specifically providing insight into the molecular underpinnings of ubiquitin signaling, Jacob's research generally bridges reductionist mechanism with cell biology, with the overarching goal of understanding how biophysical properties interact within the cellular environment to shape signaling behavior and how disease arises when these properties go awry. He is also dedicated to building new models for collaboration between academic and commercial organizations, mentoring at the interface of the two areas, and actively promoting entrepreneurship in the biological sciences. He joined the IGI as Scientific Director in May 2014