We are interested in how genomes evolve and change in response to the stresses that assault a cell. We study Candida albicans, the most prevalent fungal commensal and pathogen of humans. We are interested in how it responds to antifungal drugs and how it manages to evolve drug resistance very rapidly. Our work spans studies of chromosome structure, chromosome stability, integrity and inheritance as well as regulation of the life cycle and the cell cycle. This touches on topics including morphogenesis, ploidy, recombination and repair of damage. In addition, we develop tools that facilitate work in this important fungal pathogen.