The relatively recent evolutionary divergence and complex hexaploid genetic structure of bread wheat (Triticum aestivum L.) renders it a complex genetic system to study, in addition to its agronomic value as a major cereal crop. Nitrogen and phosphorus deficiency adversely affect crop productivity in wheat and are the two most limiting macronutrients. While the nitrate and phosphate signalling networks share common components, the molecular pathways for nitrate and phosphate signalling are not fully elucidated. Our physiological experiments showed changes in the root system architecture of wheat in response to nitrate and/or phosphate deficiency are markedly different to that of dicots. Nitrate and phosphate deficiency results in longer seminal roots in wheat whereas primary root growth is retarded and lateral root growth is promoted in response to phosphate deficiency in dicots. This suggests that underlying molecular mechanisms may also be different in wheat from what is known about nitrate and phosphate signalling of model plants. Our data show that some regulatory genes of nitrate and phosphate signalling act in a homeolog-specific and unique way in wheat under nitrate and/or phosphate deficiency conditions indicating independent regulation of the homeologs and gene dosage effects which may in part be epigenetically regulated. I aim to extend the experiments to study epigenetic regulation of wheat through histone post-translational modifications under nitrate and phosphate deficiency and integrate epigenomic and transcriptomic data which will provide insights to regulation of nitrate and phosphate signalling networks in a genetically complex and economically important crop.